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  • AssayQuant Series B

  • 260 Cedar Hill Street, Marlboro, MA 01752, USA
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A Powerful Approach for Understanding Kinase and Phosphatase Function and Identifying the Most Effective Drugs

AssayQuant’s mission is to support the development of more effective therapies for cancer, chronic inflammation, neurodegeneration, and other serious conditions.

Our team is motivated by a shared vision of reducing suffering, to build a healthier world. We stand with you at the frontier of target biology and drug discovery & development, helping you to rapidly and effectively identify the best solutions, from the vast number of possibilities.

AssayQuant's Proprietary PhosphoSens® Technology uses novel, fluorogenic sensors in enzyme recognition sequences that are carefully optimized for each enzyme to relay quantitative information on phosphorylation in real-time with less effort.
 
  • Our direct, real-time, kinetic, enzyme activity assays yield better, more reliable data than other methods, enabling better decisions regarding target biology and generation of lead candidates to empower faster movement through the drug discovery process.
     
  • Whether used in high, moderate or low throughput modes, the resulting richer information from quantitative data allows you to rapidly rank candidates by inhibition mechanism, selectivity profiling and multiple measures of potency, with covalent and reversible inhibitors and fragments.
     
  • AssayQuant has a catalog of over four hundred optimized assays, developed from curated libraries of tens of thousands of fluorogenic peptide sensor substrates, and also provides services to develop novel optimized assays for you. Why not use the best substrate for your assays, designed for your enzyme?
     
  • We will either transfer the new assay methods to you to use in your own laboratory or can provide screening, potency or profiling services, saving you time, money, and resources. Our highly skilled scientists bring years of experience with kinases and phosphatases to bear to solve your problems. Our goal is to help you get to the best candidate molecules with the highest efficacy as quickly as possible.

Company Info

We have established an experienced Leadership Team with the right expertise across key functions including Finance, Commercial Operations, R&D, Custom Testing Services, Operations and Automation.


 

We also have an active Board of Directors consisting of three members representing the main investors in the Angel round that raised $4.5 million in May 2021, and Barbara as a co-founder, CTO and major investor and Erik as a co-founder, CEO and CSO.


 

Charles Baltic is Chairman of the Board, Jeff Hoerle is Chairman of the Audit Committee and Gil Price is Chairman of the Governance and Compensation Committee. The board meets every quarter and additionally as needed. Minutes are recorded, reviewed and approved.

Since the Angel round fundraise in May 2021, our team has grown from 5 to 27 people to meet the needs of our customers and continue to accelerate our revenue growth. This includes a Senior Scientific Team that provides exceptional support, both internally and externally.


 

Our expanded team of now 27 FTEs provides quality products and services that are becoming the new “gold standard” in drug discovery, delivering improved drugs faster.

Co-founder, President, CEO, CSO, & Board Member

Erik
Linkedin
Erik is co-founder and President, CEO and CSO of AssayQuant Technologies, Inc. He has over 25 years of experience leading innovative life science tool companies, including Promega, BioSource, Invitrogen/Life Technologies, Thermo Fisher Scientific and now AssayQuant Technologies, Inc.

In his many leadership roles, Erik has built and led high-performing R&D and manufacturing teams focusing on integrating innovative technologies to enable customers across diverse market segments and drive business performance.

Co-founder, CTO & Board Member

Barbara
Linkedin
Barbara is co-founder and CTO of AssayQuant Technologies. She is currently the Class of 1922 Professor of Biology and Chemistry at MIT and has run an independent research group working in the fields of chemical biology and glycobiology at Carnegie Mellon, Caltech and MIT.

Barbara received a B.Sc.(Hon) in Medicinal Chemistry (University College London, UK) in 1979 and a Ph.D. in Synthetic Organic Chemistry (MIT, Cambridge MA). She also carried out postdoctoral studies at MIT and Brandeis University.

Chief Financial Officer

Gerry
Linkedin
Gerry is a finance and accounting executive with 30+ years of leadership experience focused on system implementation, defining roadmaps, and developing financial platforms.

He has successfully led a broad range of financial implementations impacting private equity and real estate, including investment returns and calculations, and performance reporting. 

Gerry’s finance and accounting experience is in diverse industries (Real estate, public accounting, consulting, etc.) for both public (State Street Bank, Brookfield Asset Management) and private (Hipercept, AEW Capital Management) companies.

Vice President, Commercial Operations

Michelle
Linkedin
Michelle Lyles, P.D., Vice President of Commercial Operations at AssayQuant, has 20+ years of Sales/Marketing experience ranging from early-stage Start-Ups to large global Life Science companies.

Michelle’s professional focus is dedicated to an unambiguous application/scientific focus to the sales and marketing of advanced technologies, an inspirational-aspirational philosophy to leadership and a disciplined rigor to managing business processes.

Senior Director of Discovery Technologies

Earl

Earl brings over 25 years of expertise in biochemistry, biophysics, and enzymology across multiple therapeutic areas. He has held research and leadership roles for companies like SmithKline Beecham, GlaxoSmithKline, OSI Pharmaceuticals, and numerous innovative biotechnology companies. He has explored hundreds of drug targets at the early end of the pipeline and has driven dozens of projects into and through screening and hit to lead activities.

Earl received his Ph.D. in Molecular Biophysics and Biochemistry from Yale University after his undergraduate work in Biochemistry at the University of Maryland, Baltimore County. His post-doctoral work was in Nancy Craig's lab at Johns Hopkins University, where he dissected bacterial transposition in reconstituted systems.

Director of Operations

Husam

Husam is a biotechnology leader with over 30 years of experience delivering operational excellence across disciplines, including compound and sample management, database & project management, automation, informatics, and drug discovery.

He brings unique technical and business management knowledge gained through the successful implementation of multiple complex global projects requiring both hardware and software. Husam brings the customer perspective to his work at AssayQuant from his tenure at multiple small and large biopharmaceutical companies. including Lundbeck, Wyeth, Pfizer and Evotec.

Associate Director of QCSM

Jefferson

Jeff brings over 30 years of experience to AssayQuant within the fields of chemistry and compound management. Jeff has worked in a variety of small and large companies such as Cheminpharma, Bayer, Novartis, BMS and Pfizer. Jeff started out as a peptide chemist before transitioning to analytical chemistry, primarily NMR spectroscopy and Mass Spectrometry and finally into leadership positions within Compound Management.

Jeff’s broad experience has enabled him to bring innovative ideas into compound management such as acoustic ejection mass spectrometry for the analysis of compound integrity. Jeff obtained his MBA from the University of New Haven.

Investment Highlights

 

Key Investment Highlights

Innovative growth company with accelerating revenue & margins

Enabling products and services supporting drug development. Our initial focus is on kinase and phosphatase enzymes, which comprise >30% of all FDA-approved drugs in last 3 years.

From proprietary enabling catalog products and CRO services for PhosphoSens® business:

  • Revenue growth from $1.7MM in 2020 and $2.8MM in 2021 with single digit FTEs;
  • Following Angel round investment of $4.5MM in May 2021, achieved 2022 revenue of $4MM; and through June 2023 generated a 3-year and 2-year revenue CAGR of 60% and 57% respectively, with acceleration continuing in 2023.
  • Catalog products at >75% GM and custom testing GM targeted at >55% with full automation (significant use of proceeds for raise)

Strong leadership

Visionary founders and talented senior team with the right expertise.

With extensive life science tools / pharmabiotech / CRO experience at leading companies including MKKGY (Millipore, Sigma-Aldrich), PKI, Promega, TMO (Affymetrix, BioSource, Panomics, Invitrogen) / BMY, GSK, PFE / EVO, TMO, with successful execution on translating groundbreaking science, technology integration and commercialization.

Exclusive licensee of proprietary MIT technology

Invented by Dr. Barbara Imperiali (Full Professor in Depts of Chemistry and Biology, a co-founder), with 9 issued and 2 pending patents that is being expanded by AQT.

Revolutionary PhosphoSens platform

Addressing customer needs and gaps with competitor products to solve the fundamental Bio/Pharma problem that drug development is a long, expensive and often ineffective process. We are enabling generation of improved drugs faster, creating a new gold standard.

Large addressable market

$1B to $2B for pre-clinical kinase/phosphatase assay support of drug development for the top 5 diseases, which is expected to grow 14% annually.

Accelerating revenues

From rapid adoption by leading Pharma, Biotech, CROs and academic labs.
  • Following Angel round investment of $4.5MM in May 2021, achieved 2022 revenue of $4MM; and through June 2023 generated a 3-year and 2-year revenue CAGR of 60% and 57% respectively, with acceleration continuing in 2023.
  • Integrated commercial team by end of Q2 2022, resulting in strong yr/yr growth for Q3 (1.5-fold) and Q4 (2-fold).
  • Projecting >$60MM @ 6 yrs, with additional growth potential from expansion into new technologies, target classes or future positioning for adjacent markets (including diagnostic products & therapeutic leads) to achieve >$100MM annually.

Institutional Investment Round

Seeking Institutional Investment Round of $12MM to accelerate our strong revenue growth


Financial Snapshot

  • Investment Type: Biotechnology
  • Offering Type: Equity
  • Funding Goal: $12,000,000
  • Minimum Investment Amount: $25,000
  • Large addressable market: $3B to $5B
  • New growth opportunities: >$100MM in annual revenue
  • Multiple potential exits: 6-10x sales

Financial Highlights

      • Accelerating revenues from rapid adoption by Pharma, Biotech, CROs and academic labs.

      • Following Angel round investment of $4.5MM in May 2021, achieved 2022 revenue of $4MM; and through June 2023 generated a 3-year and 2-year revenue CAGR of 60% and 57% respectively, with acceleration continuing in 2023.
      • AssayQuant has raised an additional $1 million from Future Labs Capital in October 2023.

Investor Presentation Video Gallery

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Documents

Project Title Document Title Action
AssayQuant Series B Convertible Note Summary of Terms - FAQs View
AssayQuant Series B Convertible Note Summary of Terms View
AssayQuant Series B Subscription Agreement and Convertible Note View

Investment Location

Instructions


 

A Powerful Approach for Understanding Kinase and Phosphatase Function and Identifying the Most Effective Drugs

AssayQuant’s mission is to support the development of more effective therapies for cancer, chronic inflammation, neurodegeneration, and other serious conditions.

Perks

Frequently Asked Questions (FAQ)

Equity Financing in Year Two at an Up-round Valuation – Case A
Scenario: The Company raises $4M in new capital from the Convertible Notes financing, and a Series B financing occurs in the second year of the term of the Convertible Notes, where the new Series B investor(s) contribute $12M in new equity capital, with a pre-money valuation of $36M1.

To determine if such Series B financing would be classified as a “Subsequent Equity Financing”, we would add the $4M to the $12M and therefore the total financing between the Convertible Notes financing and the Series B financing would be $16M, and greater than the $15M threshold for a Subsequent Equity Financing conversion. 

Next, we would determine how the Convertible Notes would convert as follows: 

Conversion Calculation: i. At a pre-money valuation of $36M1, the new equity shares would be valued at $14.33 per share based on a fully diluted number of shares of 2,512,0502. 

ii. Since the Subsequent Equity Financing happens in  the second year of the term of the Convertible Notes, the Convertible Notes would convert at 90% of the share price for the new investor(s), or $12.90 per share ($14.33 * 90%). 

1 Since the financing occurs in the 2nd year, a projection of $6M in annual revenues at 6X such revenues was used for the premoney valuation calculation.
2 Total number of shares includes a 15% option pool allocation. 
Equity Financing in Year Two at an Up-round Valuation – Case B
Scenario: The Company raises $4M in new capital from the Convertible Notes financing, with $3M from existing investors and $1M from new investors. All other facts are the same as Scenario 1 above.

To determine if such Series B financing would be classified as a “Subsequent Equity Financing”, we would add the $4M to the $12M and therefore the total financing between the Convertible Notes financing and the Series B financing would be $16M, and greater than the $15M threshold for a Subsequent Equity Financing conversion. 

The split of the new capital between existing and new investors in the Convertible Note Financing does not affect the calculation of whether the Subsequent Equity Financing conversion threshold of $15M is met. 

Conversion Calculation: Same result as in Case A above. 
Equity Financing in Year Four at an Up Round Valuation
Scenario: The Company raises $4M in new capital from the Convertible Notes financing, and a Series B financing occurs in the fourth year of the term of the Convertible Notes, where the new Series B investor(s) contribute $12M in new equity capital, with a pre-money valuation of $36M3. 

To determine if such Series B financing would be classified as a “Subsequent Equity Financing”, we would add the $4M to the $12M and therefore the total financing between the Convertible Notes financing and the Series B financing would be $16M, and greater than the $15M threshold for a Subsequent Equity Financing conversion. 

Next, we would determine how the Convertible Notes would convert as follows:

Conversion Calculation: i. At a pre-money valuation of $36M, the new equity shares would be valued at $14.33 per share based on a fully diluted number of shares of 2,512,0502. 

ii. Since the Subsequent Equity Financing happens in the fourth year of the term of the Convertible Notes, the Convertible Notes would convert at 80% of the share price for the new investor(s), or $11.46 per share ($14.33 * 80%). 
Equity Financing in Year One at a Flat Valuation
Scenario: The Company raises $5M in new capital from the Convertible Notes, and a Series B financing occurs within the first year of the term of the Convertible Notes, where the new Series B investor(s) contribute $10M in new equity capital, with a pre-money valuation of $24M4 

To determine if such Series B financing would be classified as a “Subsequent Equity Financing”, we would add the $5M to the $10M and therefore the total financing between the Convertible Notes financing and the Series B financing would be $15M, and equal to the $15M threshold for a Subsequent Equity Financing conversion. 

Next, we would determine how the Convertible Notes would convert as follows: 

Conversion Calculation: i. At a pre-money valuation of $24M, the new equity shares would be valued at $9.22 per share based on a fully diluted number of shares of 2,601,0622. 

ii. Since the Subsequent Equity Financing happens in the first year of the term of the Convertible Notes, the Convertible Notes would convert at 100% of the share price for the new investor(s), or $9.22 per share. 

iii. Note: In this scenario the new shares would be priced at approximately the same price per share as the Series A financing of $9.16. 

3 Although this scenario doesn’t happen until year 4, the same $36M pre-money valuation from scenario 1 was used for consistency of comparison.
4 Since the financing occurs within the first year, a projection of $4M in annual revenues at 6X was used for the pre-money valuation calculation. 
Equity Financing in Year One at a Down Round Valuation
Scenario: The Company raises $5M in new capital from the Convertible Notes, and a Series B financing occurs within the first year of the term of the Convertible Notes, where the new Series B investor(s) contribute $10M in new equity capital, with a pre-money valuation of $20M. 

To determine if such Series B financing would be classified as a “Subsequent Equity Financing”, we would add the $5M to the $10M and therefore the total financing between the Convertible Notes financing and the Series B financing would be $15M, and equal to the $15M threshold for a Subsequent Equity Financing conversion. 

Next, we would determine how the Convertible Notes would convert as follows:

Conversion Calculation: i. At a pre-money valuation of $20M, the new equity shares would be valued at $7.49 per share based on a fully diluted number of shares of 2,671,5472. 

ii. Since the Subsequent Equity Financing happens in the first year of the term of the Convertible Notes, the Convertible Notes would convert at 100% of the share price for the new investor(s), or $7.49 per share.

iii. Note: In this scenario the new shares would be priced at less than the Series A financing price per share of $9.16. 
Sale of Company for $40M - true “Change of Control” (COC) as Defined
Scenario: The Company raises $6M in new capital from the Convertible Notes from existing investors. In the third year of the term of the Convertible Notes, a third party offers to acquire all of the issued and outstanding equity of the Company (an “Acquisition”) for $40M, which would equate to $20.48 per share on a fully diluted number of shares of 1,953,2355.

Conversion Calculation: i. All equity shares of the company would be purchased by the acquiror in the Acquisition.

ii. Since this would be is a COC as defined, each individual Convertible Note holder would have the option to either (i) get repaid principal and accrued interest on their Note in full or (ii) convert the applicable principal and accrued interest into equity shares of the Company at the appropriate conversion price and then receive the amount of cash per share via the Acquisition.

iii. Since the Acquisition happens in the third year of the term of the Convertible Notes, each individual Note Holder who chooses to convert would convert their Convertible Notes into equity shares at 150% of the Series A post money valuation ($14.5M * 150% = $21.75M), which would equate to $11.14 per share.  

5 In the Acquisition scenario there would be no increase in the Option pool, therefore a reduced number of total shares is used for the fully diluted calculation.
Technical “Change of Control”, But Not A “Change of Control” as Defined
Scenario: The Company raises $4M in new capital from the Convertible Notes from existing investors, and a Series B financing occurs in the third year of the term of the Convertible Notes, where the new Series B investor(s) contributes $40M in new equity capital, with a pre-money valuation of $30M (March 2025). 

The new investment exceeds the threshold for a Subsequent Equity Financing conversion.

Conversion Calculation: i. The above scenario would result in the new Series B investor(s) owning more than 51% of the fully diluted shares of the Company, therefore this technically could be considered a change of control. 

However, this transaction would not trigger a Change of Control conversion event, as it would not meet the definition of “Change of Control” agreed in the Convertible Notes.

Therefore, this scenario would result in a conversion under the Subsequent Equity Financing calculation.

ii. At a pre-money valuation of $30M, the new equity shares would be valued at $9.55 per share based on a fully diluted number of shares of 3,142,9202.

iii. Since the new investor transaction happens in March 2025, which is in the third year of the term of the Convertible Notes, the Convertible Note Holders can convert at a price that is 85% of the share price for the new investor, or $8.12 per share ($9.55 * 85%). 
What Are the Risks Associated with the Company?

The Company currently has minimal risks. Indeed, we have systematically built anA-team and demonstrated strong execution with accelerating revenues since ourSeries A fundraiseof $4.5 million in May 2021. At that time, the company had only 5 employees and achieved $2.8 in revenue. The Management Team of the Company was almost non-existent except for Erik Schaefer, the CEO.

Since the Series A Fundraise, we have grown to 27 employees with a full Leadership/ Senior Management Team and a solid infrastructure that includes:

  • i) Commercial Operations with a lean but highly effective Sales & Marketingteam (7 FTEs) under the leadership of Michelle Lyles, Ph.D.,
  • ii) Discovery Technologies managing the custom services of the Company under the leadership of Earl May, Ph.D.,
  • iii) Inventory Management & Automated Services (IMAS)under the leadership of Jefferson Chin, and
  • iv) Finance (also Facilities, Human Resources & Project Management) under the leadership of Gerry Labonte, CFO.We also expanded from 1,500 to 9,500 sq ft and have added instrumentation (automation and microplate readers) to fuel our growth. As of June 2023, our sales were up ~2-fold year-over-year and our 3-year revenue Compounded Annual Growth Rate (CAGR)was 60%. We are on track to achieve theannual revenue goal for 2023 of $6.5 million (see further detail regarding revenue in question 2 below).

We have in place a Risk Matrix for each department that includes assessment of Impact and Probability of Occurrence, both before and after mitigations. The main risks we face are appropriate for a growth company at our stage. This includes continuing to effectively balance supply and demand for Q4 2023 and 2024 & 2025, so that we remain on track for revenue growth and operational efficiency/cash burn until we are profitable, which istowards the end of 2025. We offer both catalog products (>70% gross margin with minimal optimization so far) and custom testing services, which maximizes our ability to serve our customers. An active area of focus is taking out cost with our Custom Testing Services so that we increase gross margins to >60%, as discussed in question 6 below.

Where Do You See Sales Trending in the Next 12 to 24 Months?

As of June 2023, YTD revenue is up 122% over prior year for the same period, and AQT has had growth for the last 3-yearswith a CAGR of 60%. We have projected 74% & 80% growth for 2024 & 2025, respectively.

What Is the Best Use for Cash on the Company's Balance Sheet?

The company is reserving current cash to support the burn rate for employees, equipment and operational costs.

With the cash to be obtained through this fund raise, the priority items are as follows:

  • i) Sales & Marketing cost to include key hires for sales, and next version of the website with eCommerce,
  • ii) Research & Development for an R&D Director to coordinate the expanded portfolio of products and services, including new fluorophore derivatives and selective sensor peptide development for analysis of cell & tissue lysates,
  • iii) Manufacturing & Custom Testing where we are integrating full automation to increase capacity & margins, for which additional equipment & software will be purchased.
How Does the Company Plan to Raise Capital in Order to Fund Future Growth?

The company is in the process of raising capital under a Convertible Debt Structure while also raising equity capital as a Series B Round. Both of these mechanisms for raising capital are being coordinated through an agency. The Company has raised $4.4 million via the current Convertible Debt offering mainly through its current investors (86%) and other close relationships.

Who Are the Emerging Competitors in the Industry in Which You Operate?

Despite the large ($1 billion+ market size) and high amount of activity in the kinase inhibitor space (as demonstrated by large IPO’s or Series A/B/C’s, increasing approvals by the FDA and other agencies, and several market reports forecasting inhibitor sales to be ~$160 billion by 2032), there has been very little innovation with kinase assay technologies in the last 20 years. The PhosphoSens platform from AssayQuant incorporates innovative technology out of MIT (invented by a co-founder) that provide a simple and powerful approach that is enabling improved drugs to be created faster and at reduced cost.

The strong collection of features and benefits with PhosphoSens technology is unmatched and is allowing us to both take and create market share. The competitor view is shown below:

What Part of the Business Is Giving You the Most Trouble Now?

We currently provide a custom service for full kinome profiling with >400 wild-type kinases, which is market leading from a menu perspective alone. Moreover, this service is performed kinetically with our PhosphoSens platform, providing higher accuracy and precision and greater information about the functionality of both the kinase targets and the drug.

We also run this at low or high ATP, where the latter provides a physiological correlate, and we are the only company to offer this across >400 targets with a single platform based on functional activity measurements. Initially, this profiling service was set up and performed manually to demonstrate feasibility and market adoption (we have shown both). In 2023 we have implemented the first phase of full automation with robotics purchased with the Series A funding. To meet demand and systematically take out cost to increase gross margins to >60%, we have several continuous improvement projects ongoing across the company.

Next steps are focused on integrating the Scigilian database and the Arktic freezer sample retrieval system for complete control of all reagents, data analysis and report generation. Another initiative is to begin purchasing a significant amount of bulk kinases to obtain much lower pricing, which is critical since our primary vendor for kinases increased cost to usby 1.5-foldearly in 2023 (this was a combination of reduced discount and increased list price).

We have pushed back on pricing and will receive an additional discount with bulk purchases.We are charging a premium for the profiling service relative to the market, so our cost reduction initiatives are high priority, and these efforts are proceeding as planned. Importantly, we have validated market demand for our Profiling Service and revenue has already increased toapprox. $700K or 23% of total sales in the first half of 2023.

Our profiling service informs clients about the specificity of their compounds. Historically, even many FDA-approved kinase inhibitors are quite “dirty”, meaning that that they exhibit many off-target liabilities that contribute to the side-effects of the drug (see figure below on left side).

In contrast, customers working with us are able to create highly selective drugs (see figure below on right side).

How Close Is Wall Street in Terms of Estimating Your Company's Earnings Results?

Not applicable, as we are a privately held company and earning results are not made public.

What is the company's reputation for services, products?

We have accelerating sales fueled by repeat orders and new customers and both reflect the increasingly compelling reputation we are building. This includes outstanding technical support and a marketing focus that is “Science First”, thereby delivering a streamlined and informative message that resonates with our customers. When clients move from one company to another, they bring their loyalty to us with them. We have focused on delivering quality and essentially have no complaints.

Are there any complaints on file against the company with BBB or a local consumer protection agency?

No, the company has never had a lawsuit against it, nor any complaints with any agency.

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Terms

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$6,122,380 raised of $12,000,000 goal

Investment Summary

  • Deal Type: Convertible Note
  • Issuer: AssayQuant Technologies
  • Investment Type: Institutional
  • Funding Goal: $12,000,000
  • Hold Period: 60 Months
  • Min. Investment: $25,000
  • IRA Eligible: Yes
  • Investor Relations: invest@assayquant.com
  • AssayQuant Investment Round
  • Video Gallery
    • Contact CEO: Erik Schaefer, Ph.D.
    • Email: erik.Schaefer@assayquant.com

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